A static analysis of three-dimensional sandwich beam structures by hierarchical finite elements modelling

A static analysis of three-dimensional sandwich beam structures using one-dimensional modelling approach is presented within this paper. A family of several one-dimensional beam elements is obtained by hierarchically expanding the displacements over the cross-section and letting the expansion order a free parameter. The finite element approximation order over the beam axis is also a formulation free parameter (linear, quadratic and cubic elements are considered). The principle of virtual displacements is used to obtain the problem weak form and derive the beam stiffness matrix and equivalent load vectors in a nuclear, generic form. Displacements and stresses are presented for different load and constraint configurations. Results are validated towards three-dimensional finite element solutions and experimental results. Sandwich beams present a three-dimensional stress state and higher-order models are necessary for an accurate description. Numerical investigations show that fairly good results with reduced computational costs can be obtained by the proposed finite element formulation

Resuscitative thoracotomy for non-traumatic tension viscerothorax

A case of acute herniation of small bowel in thorax after blunt trauma is described, emphasizing the necessity ao a resuscitation emergency thoracotom

Hierarchical one-dimensional finite elements for the thermal stress analysis of three-dimensional functionally graded beams

In this work, the thermoelastic response of functionally graded beams is studied. To this end, a family of advanced one-dimensional finite elements is derived by means of a Unified Formulation that is not dependent on the order of approximation of the displacements upon the beam cross-section. The temperature field is obtained via a Navier-type solution of Fourier’s heat conduction equation and it is considered as an external load within the mechanical analysis. The stiffness matrix of the elements is derived via the Principle of Virtual Displacements. Numerical results in terms of temperature, displacements and stresses distribution are provided for different beam slenderness ratios and type of material gradation. Linear, quadratic and cubic elements are used. Results are validated through comparison with three-dimensional finite elements solutions obtained by the commercial software ANSYS. It is shown that accurate results can be obtained with reduced computational costs

Sermones Gabrielis Barelete de Sanctis : tomus secundus ...

BHR/A-029-315 (2)(BIB LVL) w-FONDO ANTIGUO(ES-GrU)b18204351-34cbua_ugrUGRALABarletta, Gabriele (O.P.)Sermones Gabrielis Barelete de Sanctis :Lugduni :ci, [11] h.Port. con orla tip.Texto a dos col.Iniciales grab.ColofónEncuadernado con: Gabrielis Barelete sermones : tam quadragesimales, quam de sanctis ...Datos de impresión tomados del colofónEsta digitalización se ha realizado con fondos del Ministerio de Cultura y Deport

Sermones Gabrielis Barelete de sanctis : tomus secundus ... ordinis praedicatorum ... adiecta est in huium secunde partis fine locipletissima tabula alphabetica ..

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2013Pie de imp. tomados de colofónMarca tip. en última h.Sign.: 2a-2o8Port. orlad

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate age-related metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD. Our findings suggest NR as a viable clinical avenue for neuroprotection in PD and other neurodegenerative diseases

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI